Top Trending Startups in San Diego

In November, several emerging startups have taken off in the startup space in San Diego. Leading the charge is Splitero , the top trending topic, with a search volume of 5.4K and an impressive +7800% growth rate.

TOP COMPANIES - UPDATED NOV 2025
35 Results

1. Splitero

Regular Growth

A company that provides financial solutions, specifically focusing on home equity. They offer homeowners the ability to access their home equity without taking on additional debt through a home equity investment model,…

Startup Details
San Diego
Location
Jan 2021
Founded Date
Data & Forecast
+7800%
2 years Growth
5.4K/mo
Search Volume
businessfinancereal-estateinvestingpersonal-finance
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
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2. Shield AI

Exploding Growth

Artificial intelligence robotics company focused on developing and deploying AI systems to protect service members and innocent civilians. Shield AI differentiates itself by creating advanced autonomous systems that can…

Startup Details
San Diego
Location
May 2015
Founded Date
Data & Forecast
+317%
2 years Growth
40.5K/mo
Search Volume
businesstechnologyindustryairoboticsautomation
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
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3. outseta

Exploding Growth

Membership software platform designed to help founders monetize and grow SaaS or membership businesses. It offers a comprehensive suite of tools including subscription management, email marketing, CRM, help desk, and…

Startup Details
San Diego
Location
Jan 2016
Founded Date
Data & Forecast
+206%
2 years Growth
5.4K/mo
Search Volume
businesstechnologysoftwareproductivityprogrammingautomation
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
Start 7-Day Free Trial

4. Fatty15

Exploding Growth

​Fatty15 is a dietary supplement that delivers C15:0, also known as pentadecanoic acid, an essential fatty acid recognized for its potential health benefits. Developed by Seraphina Therapeutics, Fatty15 aims to support…

Startup Details
San Diego
Location
Jan 2020
Founded Date
Data & Forecast
+163%
2 years Growth
12.1K/mo
Search Volume
healthsupplementsnutrition
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
Start 7-Day Free Trial

5. Capstan Therapeutics

Exploding Growth

Biotechnology company focused on developing targeted in vivo RNA technologies. Capstan Therapeutics aims to expand therapeutic possibilities for patients through advanced RNA-based treatments, differentiating itself by…

Startup Details
San Diego
Location
Jan 2021
Founded Date
Data & Forecast
+207%
2 years Growth
2.4K/mo
Search Volume
businesshealthsciencepharmahealthcare
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
Start 7-Day Free Trial

6. ClickUp

Exploding Growth

All-in-one productivity platform designed to help teams collaborate, plan, and manage various tasks and projects. It offers a unique hierarchy system that allows users to create a scalable structure tailored to their…

Startup Details
San Diego
Location
Jan 2017
Founded Date
Data & Forecast
+126%
2 years Growth
1.5M/mo
Search Volume
businesstechnologysoftwareproductivityworkplacemarketing
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
Start 7-Day Free Trial

7. lifepro

Exploding Growth

Company that offers a range of fitness and recovery equipment, particularly focusing on vibration plates designed for joint relief, muscle relief, strength boost, and overall fitness. LifePro differentiates itself by…

Startup Details
San Diego
Location
Jan 1986
Founded Date
Data & Forecast
+118%
2 years Growth
49.5K/mo
Search Volume
businesshealthecommerceretailfitnesssleep
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
Start 7-Day Free Trial

8. Semantic AI

Exploding Growth

Technology that focuses on creating interpretable and meaningful data from the beginning of the data lifecycle. It ensures data is well-structured and semantically rich, making it easily understandable and usable. This…

Startup Details
San Diego
Location
Jan 2001
Founded Date
Data & Forecast
+364%
2 years Growth
1.9K/mo
Search Volume
businesstechnologysoftwareaicybersecurity
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
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9. Drata

Exploding Growth

Continuous security and compliance automation company focused on building trust across the cloud. Drata differentiates itself by providing automated monitoring and evidence collection to streamline compliance processes,…

Startup Details
San Diego
Location
Jul 2020
Founded Date
Data & Forecast
+150%
2 years Growth
22.2K/mo
Search Volume
businesstechnologysoftwarecybersecurityautomation
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
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10. Concert Health

Exploding Growth

Company that focuses on integrating behavioral health care into primary care settings using a collaborative care model. Concert Health differentiates itself by working with medical groups and health systems to…

Startup Details
San Diego
Location
Jan 2016
Founded Date
Data & Forecast
+583%
2 years Growth
2.4K/mo
Search Volume
businesshealthhealthcaremental-health
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
Start 7-Day Free Trial

11. Trust & Will

Exploding Growth

Online service offering legal forms and information for estate planning, including wills, trusts, and guardianships. It differentiates itself by providing a user-friendly platform that simplifies the process of creating…

Startup Details
San Diego
Location
Oct 2017
Founded Date
Data & Forecast
+211%
2 years Growth
90.5K/mo
Search Volume
businesstechnologyfinancelegalproductivity
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
Start 7-Day Free Trial

12. Gretel ai

Exploding Growth

Platform offering tools for generating anonymized and secure synthetic data through APIs, facilitating innovation while maintaining data privacy. Gretel AI differentiates itself by providing robust data privacy…

Startup Details
San Diego
Location
Jan 2020
Founded Date
Data & Forecast
+125%
2 years Growth
1.6K/mo
Search Volume
aiautomationcompanytechnologyfinancesoftwarebanking
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
Start 7-Day Free Trial

13. Chosen foods

Exploding Growth

Company specializing in high-quality avocado oil and related products, including pure avocado oil in various sizes and avocado oil spray. Known for their quality and purity, Chosen Foods differentiates itself by…

Startup Details
San Diego
Location
Jan 2010
Founded Date
Data & Forecast
+100%
2 years Growth
9.9K/mo
Search Volume
businessfood-beveragefoodgrocerycpg
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
Start 7-Day Free Trial

14. Coral Vita

Exploding Growth

Company focused on restoring coral reefs by growing and transplanting resilient corals. Coral Vita employs advanced techniques to establish a global network of coral farms, aiming to produce billions of corals annually…

Startup Details
San Diego
Location
Jan 2017
Founded Date
Data & Forecast
+41%
2 years Growth
1K/mo
Search Volume
businessindustrylifestyleecotraveleducation
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
Start 7-Day Free Trial

15. FutureProof

Exploding Growth

Performance marketing company that leverages artificial intelligence to transform first-party data into personalized marketing strategies. FutureProof differentiates itself by utilizing advanced AI algorithms to deliver…

Startup Details
San Diego
Location
Jan 2019
Founded Date
Data & Forecast
+67%
2 years Growth
22.2K/mo
Search Volume
businesstechnologyfinanceaiinsurance
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
Start 7-Day Free Trial

16. Sun Genomics

Regular Growth

Company specializing in creating custom probiotics tailored to an individual's gut microbiota. Their flagship product, Floré, utilizes microbiome testing to personalize probiotics aimed at improving digestion, energy…

Startup Details
San Diego
Location
Jan 2016
Founded Date
Data & Forecast
+80%
2 years Growth
590/mo
Search Volume
businesstechnologyhealthsupplementshealthcareretail
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
Start 7-Day Free Trial

17. Proven

Exploding Growth

Hiring tool designed for small businesses, allowing employers to manage the hiring process on the go through native apps for iOS and Android. Proven differentiates itself by enabling employers to review resumes, respond…

Startup Details
San Diego
Location
Jan 2007
Founded Date
Data & Forecast
+65%
2 years Growth
49.5K/mo
Search Volume
businessindustrysciencelegalproductivitymarketing
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
Start 7-Day Free Trial

18. Galaxy treats

Exploding Growth

Brand specializing in high-quality, great-tasting products made from hemp, mushrooms, and blue lotus. Galaxy Treats differentiates itself by offering free shipping on orders over $30 and providing a satisfaction…

Startup Details
San Diego
Location
Jan 2022
Founded Date
Data & Forecast
+43%
2 years Growth
2.9K/mo
Search Volume
ecommercesupplementsmental-health
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
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19. Lively root

Exploding Growth

Service that delivers farm-fresh plants to your doorstep, aiming to create personal green spaces for customers. Lively Root offers online ordering and delivery services, making it convenient for customers to incorporate…

Startup Details
San Diego
Location
Jul 2020
Founded Date
Data & Forecast
+233%
2 years Growth
2.9K/mo
Search Volume
businesshomeecommerceretailhome-decor
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
Start 7-Day Free Trial

20. Home Assistant

Regular Growth

Open-source home automation platform that focuses on privacy and local control. It allows users to control and automate various smart home devices and services from a single, unified interface, supporting a wide range…

Startup Details
San Diego
Location
Jan 2013
Founded Date
Data & Forecast
+48%
2 years Growth
368K/mo
Search Volume
technologyhomesoftwareaiprogrammingautomation
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
Start 7-Day Free Trial

21. Stonehenge Health

Regular Growth

Company that offers a range of health supplements aimed at supporting various aspects of health such as digestion, immune function, joint health, and nerve health. Stonehenge Health differentiates itself by providing…

Startup Details
San Diego
Location
Dec 2022
Founded Date
Data & Forecast
+65%
2 years Growth
12.1K/mo
Search Volume
healthsupplementsnutritionhealthcare
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
Start 7-Day Free Trial

22. Vetology

Regular Growth

​Vetology is a company that provides artificial intelligence (AI) and teleradiology services tailored for veterinary practices. Their platform offers automated AI radiology reports, teleradiology services delivered by…

Startup Details
San Diego
Location
Jan 2018
Founded Date
Data & Forecast
+75%
2 years Growth
1.6K/mo
Search Volume
technologyhealthaihealthcareautomation
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
Start 7-Day Free Trial

23. AttackIQ

Exploding Growth

Company specializing in breach and attack simulation products for security control validation. It emulates adversary tactics, techniques, and procedures based on the MITRE ATT&CK framework, providing organizations with…

Startup Details
San Diego
Location
Jan 2013
Founded Date
Data & Forecast
+53%
2 years Growth
3.6K/mo
Search Volume
businesstechnologycybersecurity
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
Start 7-Day Free Trial

24. Cloudbeds

Regular Growth

Hospitality software company that provides solutions to help hoteliers manage their operations and enhance guest experiences. Cloudbeds offers a comprehensive platform that includes property management, booking engine,…

Startup Details
San Diego
Location
Jan 2012
Founded Date
Data & Forecast
+28%
2 years Growth
49.5K/mo
Search Volume
businesstechnologysoftwareproductivityautomation
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
Start 7-Day Free Trial

25. everbee

Regular Growth

Software service provider specializing in Etsy product research and revenue analytics. It helps users analyze product performance and market trends on the Etsy platform, offering insights to optimize their listings and…

Startup Details
San Diego
Location
Jan 2021
Founded Date
Data & Forecast
+56%
2 years Growth
40.5K/mo
Search Volume
businesstechnologyecommerceretailmarketing
Growth
Peaked
Regular
Exploding
Volatility
High
Medium
Low
Speed
Slow
Medium
Exponential
Seasonality
High
Medium
Low
Members Only
Start 7-Day Free Trial
Showing 1-25 of 35 Results

About Startups in San Diego

Interest in San Diego startups continues to surge this November. Leading the charge is Splitero , founded in Jan 2021, with 5.4K monthly searches and an impressive +7800% growth. Runner-up Shield AI, launched in May 2015, also shows strong engagement with 40.5K people searching for it each month. outseta rounds out the top three. Established in Jan 2016, they’ve built steady momentum, seeing 5.4K monthly searches and +206% growth. Together, these rising brands highlight how San Diego’s startups are becoming increasingly attractive to both consumers and investors.

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